Oh boy it’s my time to shine!

I’m working in aging right now. Heard of Dr. David Sinclair since he was the corresponding author on a paper I was curious about… So this is what his lab is doing.

Two important disclaimers:

• Success in cellular research rarely translates to something viable in the clinic. A lot of chemicals don’t behave the same way in cells as in actual animals or humans. Heck, a good number of phase 2 drugs even fail, and these haven’t even made it into phase 1… so I wouldn’t be too optimistic about them.
• The journal Aging is not the most prestigious journal especially for someone working at Harvard Medical School (HMS) to be honest. I’d be more excited if this was published in Nature Aging or Nature Communications or something. If this ever gets published in New England Journal of Medicine (a very prestigious journal only for clinical studies) then we have some news.

The link between cell senescence and aging is something actively being studied tho.

And, if anyone is curious about this topic: I’m also very actively following Dr. Vadim Gladyshev who is also from HMS and is working in aging, I believe he is doing some wet lab-biology on a similar area as well. Feels like his research is sometimes a bit ahead of his time but I think his work has great potential.

For god’s sake temperatures above 40 Celsius are dangerous and claims like this will literally kill some people… But again, after everything happening in the last 3-4 years it’s hard to imagine conservatives putting other folks’ health and safety as a priority

I wouldn’t be surprised if someone does. I mean banks also just shuffle money around and guess who has a bunch of cash lying on hand so… Goes back to the gold rush era, but there are folks who mine the gold and folks who mine the miners

Also some tech companies can be at a loss for years but run on VC money

So… I don’t know, but again I wouldn’t be surprised if they are making something to keep this nonsense going

Ah… so you’re specifically mentioning about the news article in question?

If you repay the loan, [your NFT token] comes back home. If not, [the token] gets a new owner. Simple as that!

I guess this explains everything… Probably just ppl hustling each other lol. And I assume given what types of shady characters are into NFTs, there are probably a lot of them who want to hustle another person out of some cash

I daily-drive Organic Maps, works very well, uses pre-downloaded maps, & allows OSM contribution. Ofc it’s reliant on OSM so may not work perfectly depending on the location

mailbox.org and skiff are „too expensive“ with 3€/month.

Ah… I do use mailbox.org and I’ve self-hosted with docker-mailserver before.

I agree, selfhosting mail is a really big pain, and at least where I live most ISPs don’t open the ports necessary for mailservers, so I had to spin up my own server & it was more expensive than just using a mail provider. Could potentially be the cheapest option if I could host it from home & just use a RasPi or something

I’m happy with mailbox.org; the Standard Tier price is 2.50 Euro/mo if paid in full if that helps. Probably not the cheapest option especially since it’s not unlimited, but they do allow domain matches at Standard tier or above, and there are other goodies like calendar/video conferencing/cloud storage & stuff.

Ohhh so that’s why… So the rice actually does do something? But I think the marketer who designed this needs to be sent back to high school to retake biology or sth

Thanks! Wowzers I’ve never heard of Nature Food, didn’t realize this journal had such a high impact factor. A few things of interest to me from the article…

• Vegans are one standard deviation younger than heavy-meat-eaters and eat fewer calories… although they should have adjusted for the difference
• This didn’t show on the fancy Monte Carlo simulation they did, but vegans emit much, MUCH less methane than any other group
• Literally any group is significantly better than heavy meat-eaters, especially low meat-eaters or below

The questionnaire they used to determine categories:

• Do you eat any meat (including bacon, ham, poultry, game, meat pies, sausages)? (Vegans, vegetarians and fish-eaters respond ‘No’.)
• Do you eat any fish? (Vegans and vegetarians respond ‘No’.)
• Do you eat any eggs (including eggs in cakes or other baked goods)? (Vegans respond ‘No’.)
• Do you eat any dairy products (including milk, cheese, butter, yoghurt)? (Vegans respond ‘No’.)
  And meat-eaters are divided by grams of meat eaten per day: <50 g/d, 50-100 g/d, >100 g/d. Apparently one patty from McDonald’s (Big Mac has two) is like 45 grams of beef so…

I mean the conclusions aren’t anything surprising, cows are literally one of the major sources of environmental damage… But it does provide some way moving forward I suppose. I suspect banning steakhouses would have a much better impact than forcing everyone to be vegan lol

(insert astronaut meme) never has been

Jokes aside… This is my personal philosophy & probably won’t align with everyone’s. As someone who started science quite young, I realized quite early that beyond societal issues, literally nothing is “meaningful”… If Earth itself will be gone in a few billion years, might as well practice some optimistic nihilism and do some stuff with whatever life I have. There’s still stuff to do even if society doesn’t prioritize ppl like me

Daily drive Gnentoo, not sure if I could ever wholeheartedly recommend it since it’s not really accessible for beginners…

If I need a VM I’d probably spin up an Arch or Alpine since they are relatively minimal & are not that difficult to set up once you’re familiar with stuff (well Arch is one-command setup now). For servers… pretty much Debian always since that’s what everyone supports

Stability-wise… I guess it depends on what type of “stability” I want? If I meant stability by having stable programming environments then it’s not compatible with having new updates, Debian probably would be best for that. If I meant stability by the system not breaking too often, then most rolling release distros are probably fine? Arch/Gentoo have a lot more room for user error which is probably where most of the instability comes from, but otherwise they typically don’t have too many issues I believe. Fedora is great but there’s been some issue with RHEL going close-source, so I guess some ppl won’t want to support that endeavor

Yes and yes! Couldn’t contribute that much but I try to

I think having a highly important FOSS project that is not controlled by a company known for shutting down many of its beloved products (I’m talking about you Google) is pretty nice…

Also I think map quality is location-dependent. I live in a large metropolitan area in Southern US; OSM is usable, but there are no house/building numbers, and a good number of businesses are missing. In contrast I think the map is a lot better in Chicago which is a lot more pedestrian-friendly? Also, when I looked at Germany it seems OSM is on-par or better than Google Maps… in fact one of the larger rental websites use OSM instead of Google Maps (imagine Zillow doing it in US lol)

Interesting, I did drive for Uber Eats during the pandemic a bit…

I guess the main “backlash” is because these few companies have to pay minimum wage now? Drivers are gig workers so have been treated as independent contractors so far: a.k.a. no employee benefits, absolutely no minimum wage… The flexibility might sound alright to some on first glance, but the more you think about it the worst it gets. And yeah these companies basically made money by giving the false pretense that you can have a flexible work schedule but then squeeze profits out from both ends

So to get back to this… I guess these companies are arguing about this law not just because they are greedy for a few extra bucks, but because mandating them to pay minimum wage might straight-up bankrupt their businesses? I don’t mind tho… Uber got to where it is today by being a loss leader & drove out the cab companies. Might as well let 'em taste a bit of their own medicine for all the shitty gig economy they brought to us

Out of curiosity… Anyone use the Steam Deck as a computer beyond just gaming? I don’t play games that much but I’d love a decent spec portable computer that I can also use to play video games, the price is quite generous given what its specs look like so…

If fingerprint protection is what I want, LibreWolf comes with a very sensible default as compared to stock Firefox. If I am familiar enough with about.config and stuff then hardened Firefox can reach bonkers levels of privacy as well

If a Chromium-based browser is required that has Brave’s level of privacy protection but none of the crypto nonsense… Yeah I’m not aware of any as of right now. Maybe once the Duckduckgo Browser becomes available?

I had a good bit of thought about this too… This kind of mindset should never be allowed in customer-facing fields in the first place (cough cough all the social media privacy hellhole we are in today…), let alone ones that risk human lives tbh.

Not sure how much of it is “predatory” behavior and how much of it is just a combination of being a masterful salesman + being really, really dumb, “drinking his own Kool-aid”… The dude was piloting the sub on every expedition after all

Holy hell

Excellent read. Have just re-posted this on 'key, thanks for sharing this.
I agree that Meta is doing something very dangerous to the fediverse… hope they could be stopped in their tracks.

Ah so there are some people on the fediverse who believe that any restriction is bad… Like the ppl who think domain blocks are too strict and stuff like that.

Pretty much everyone I’ve seen on Mastodon knows that Meta is bad. However, I’ve seen quite a few people echoing the sentiment that “hey I know Meta is bad but blocking is wrong & they haven’t done anything wrong on the fediverse”. The thought comes across as a bit naive to me but… to each their own.

From my paltry observations it seems like opinions about federating with Meta spread into the following:
1: All for-profit corporations bad, so no federation
2: Meta bad, so no federation
3: Meta bad, but wait & observe first
4: Growing the influence of fediverse is usually preferred
5: Free speech for all

Honestly the article resonates with me a lot. I assume many old-guards of Mastodon are ppl who are fully aware of how federation works & are somewhat left-leaning and anti-capitalist, so they have a tendency to not want to federate with Meta.

So it certainly doesn’t help that a few very influential people signed the NDA to join the Meta meeting, which would almost signal that they are more right-leaning (which is not what most people are like on fedi). Regarding the NDA part: people sign NDAs for too many things in pharma (my undergrad field) so I didn’t realize it was such a big deal… I think it probably rubbed too many people in the wrong way.

Also, for large general instances, I wouldn’t be surprised if many people have ideological differences with their admin or their neighbors, which probably resulted in some “fun” discussions.

Finally, PSA: I know some people hate their admins now but please do not ever send death threats to people, seriously