https://www.techspot.com/bestof/amd-x670-motherboards
Hard to go wrong with the Asrock Taichi that Wendell from Level1Techs is also a fan of. Looks like memory will be your limiting factor and with VMs being part of the equation, 128gb seems like a good idea.
I am curious how well adobe software can use a dgpu in a vm. I understand things have gotten much better for gaming and maybe that’ll translate into other gpu intensive tasks.
A good source of info: https://forum.level1techs.com
Welcome to the rabbit hole of selfhosted note-taking apps. https://selfh.st/apps/?tag=Note-Taking
Unfortunately, this is going to be a bit of a journey. You’ll probably end up going through a few of these options until you find one that works for you and fits your workflow.