Yep

Yes, there are side effects. They vary depending on the length of treatment (generally patients are not allowed to stay on them indefinitely to mitigate this) and the medication used, but puberty blockers have been used for ~40 years now and we have a good understanding of the risks. GnRH agonists are the most common type of puberty blocker used today, and the typical side effects are:

• Hot flashes
• Gynecomastia
• Fatigue
• Weight gain
• Decreased libido and erectile function

These side effects generally end once treatment stops, whether switching to hormone replacement therapy or stopping all gender-affirming treatment. These side effects are typical of low sex hormone levels in general, and are generally annoyances that can be managed rather than major risks that are likely to harm the patient long term. It’s also worth noting that some of these are seen as neutral or even positive to some patients - e.g. patients who were assigned male at birth and are interested in feminizing treatment often consider gynecomastia and decreased erectile function as positive effects.

When puberty blockers are continued for longer periods of time, there are additional risks which grow with the duration of the treatment:

• Reduced bone density, which can increase risk of or worsen osteoporosis
• Metabolic issues, which can worsen weight gain or diabetes in particular
• Having puberty delayed by any means tends to result in a child growing taller than they would otherwise

These risks are more serious, which is why puberty blockers are not prescribed indefinitely. For gender affirming treatment, puberty blockers are generally prescribed for up to two or three years, depending on local regulations and the patient’s tolerance of the treatment. After this period, patients have the option of either continuing gender affirming treatment with hormone replacement therapy (so that they can experience a different puberty than the one typically associated with their birth sex), or stopping treatment and allowing puberty to run its course as usual.

It’s also worth noting that puberty blockers are not considered in a vacuum - the risks are considered against the risk of allowing puberty to continue as usual. For children with gender dysphoria, puberty is often a severely traumatic experience. This can cause or worsen depression and suicidality, and can leave a transgender person with sexual characteristics they do not want and will have to treat later with riskier and/or more intense forms of treatment like surgery. The risks of puberty blockers are comparatively mild, which is part of why the side effects are regarded as safe for transgender patients.

Lastly, I’ll also note that all of this treatment involves mental health professionals as well. While adults in some regions can choose to start gender affirming treatment on their own without needing a formal diagnosis, treatment for children requires much more work and dedication. Typically, a minor who wants to begin gender affirming treatment for gender dysphoria will need:

• Consent from at least one parent
• A diagnosis or letter of support from a mental health practitioner who’s seen them as a patient
• A doctor or endocrinologist who can prescribe the medications
• Ongoing check-ups while they’re undergoing treatment, to assess both their physical health (physical exams, blood work to check hormone levels and organ function) and mental health (sessions with a mental health practitioner to make sure that the treatment is actually benefiting their mental health and consistent with their identity)

No, barring some other condition, puberty resumes once you stop using puberty blockers. There are increasing risks of side effects when staying on puberty blockers for more than a couple years, so it’s usually a temporary measure to give children with gender dysphoria more time to explore their identity without subjecting them to the irreversible effects of puberty yet. As a result, doctors won’t allow a patient to stay on puberty blockers permanently (barring outliers where it would actually be safer to do so, e.g. because of cancer risk associated with sex hormones). There are two typical outcomes:

1. The patient determines that they would like to transition medically, and will transition from puberty blockers to hormone replacement therapy according to their goals. This essentially allows them to replace the pubertal effects typically associated with their birth sex with something else depending on the regimen.
2. The patient determines that they don’t want to transition medically, and stops puberty blockers without starting hormone replacement therapy. At this point, puberty begins/resumes on its own as usual.

You can’t stop people from having sex, so it’s best to give them the education and healthcare necessary to reduce risks.

Each table contains one column with the patches and one column without the patches - the hardware is unchanged. The different tables are to measure the impact of the patches across different hardware.

Note that Mullvad no longer allows port forwarding, which can make it harder to torrent effectively

Google has one, but it’s still very small at the moment.

The vast majority of Google’s revenue comes from advertising, which will remain relevant even if search more or less dies. They put ads in almost every other one of their products, not to mention the ad space they buy and then resell on other sites.

What was the pre-release story for BZ? I played it this year and thought the story was fine, though it didn’t manage to recapture the feelings of mystery and discovery of the first game

Gonads are either testes or ovaries (at least for humans)

And then there’s Mr. Robot in its own tier, using actual real-world tools and frameworks, with realistic flags and everything!

I’m just glad pixels have finally been coming around on more updates. I was forced to replace my Pixel 3 if I wanted to use it with the BYOD program at work because it had reached the end of the update cycle, even though it was in fine condition and still met my needs. Now I’m on a Pixel 7, and hopefully I can get the full five years of use from it.

Hmm, I bet most of the functionality could be replicated using a browser extension. Pretty much the only thing I think you wouldn’t be able to access would be saved passwords and credit cards. Networking might be an issue as well if you were trying to set up an ad-hoc system like KDE connect uses.

The NLRB ruled that the nature of their work makes them employees of both Cognizant and Google, despite whatever those companies try to classify them as, and that both are required to negotiate with the union. Google is now just flat-out refusing to respect that decision.

The devs followed up indicating that the tweet about delisting the game on Jan 1st was a joke, but it’s still a shitty situation for developers

It’s not totally clear yet. My role is fully remote, so the info I have is second-hand from memos and word of mouth. The company has apparently been using an automated system to send scary emails to people not badging in (with their manager CCed), but I don’t know what happens if you just ignore those. Memos have made vague threats of implications for performance reviews, but those haven’t happened yet since they announced they would be tracking badge data.

My company only started cracking down on it a couple months ago. Nominally the majority of employees were supposed to be working in the office three days a week as of April 2022, but most of the roles don’t require physical presence so people just kept working from home. Now the company has shifted to tracking badge data to make sure people are actually coming into the office, despite three years of data demonstrating we’re just as productive as home…